Is St. Louis in Missouri or Illinois?

The city of St. Louis is in Missouri. The metro area spans both states, with East St. Louis and other communities in Illinois across the Mississippi River.

What Fortune 500 companies are in St. Louis?

Major headquarters include Emerson Electric, Centene, Reinsurance Group, Edward Jones, and Enterprise Holdings. St. Louis has more Fortune 500 headquarters than most similarly-sized metros.

What timezone is St. Louis?

St. Louis operates on Central Time (CT), aligned with Kansas City, Chicago, and the central US.

Is Anheuser-Busch still in St. Louis?

Yes, despite being owned by AB InBev, Anheuser-Busch maintains major operations in St. Louis including the historic brewery. The company remains a significant employer and civic presence.

St. Louis Phone Numbers

Get a St. Louis, MO Phone Number

The Gateway to the West remains a Fortune 500 hub, with Emerson, Enterprise, and Centene headquartered here. The iconic Arch symbolizes a city that blends Midwest values with corporate headquarters and world-class healthcare. Phone2 connects you to this underrated business center.

Area Code

314

State

Population

300,000

Timezone

Central Time (CT)

All Area Codes

314 636

Last updated: October 21, 2025

St. Louis, MO

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Business in St. Louis

St. Louis punches above its weight in Fortune 500 headquarters. Emerson Electric, Enterprise Holdings, Centene, and Bunge are based here. Washington University and BJC HealthCare anchor healthcare and research. The metro offers low costs, strong universities, and a corporate culture unusual for a mid-sized city.

Why Choose Phone2 for St. Louis?

A 314 number is quintessential St. Louis, identifying you with the city's corporate headquarters and regional market. Whether serving Fortune 500 companies, healthcare, or local businesses, Phone2's local numbers establish Gateway City presence.

Key Industries in St. Louis

Corporate Headquarters

Emerson Electric, Enterprise Holdings, Centene, and other Fortune 500 companies are headquartered here. Professional services, finance, and corporate support cluster around these anchors.

Healthcare & Research

Washington University Medical School and BJC HealthCare form a premier academic medical center. Biotech research, medical devices, and healthcare services are substantial employers.

Manufacturing & Distribution

St. Louis's central location makes it a logistics hub. Aerospace, food processing, and industrial manufacturing employ thousands. Anheuser-Busch remains a major presence.

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Frequently Asked Questions about St. Louis

St. Louis city uses 314, one of the original area codes. The 636 code covers western suburbs in St. Louis County. These codes identify the Missouri side, while 618 covers the Illinois side of the metro.

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