Area code 573 covers much of central and southeastern Missouri, including cities such as Columbia, Jefferson City, Cape Girardeau, Rolla, and Poplar Bluff. Introduced in 1996 from a split with 314, this area code spans a mix of university towns, state government, agriculture, and healthcare hubs. Columbia is home to the University of Missouri, driving innovation and research. Jefferson City, the state capital, provides administrative and political stability. Cape Girardeau and surrounding communities contribute through healthcare systems and regional commerce. Rolla houses Missouri University of Science and Technology, one of the nation’s top engineering schools. 573 is a well-rounded area code that signals connection to the Midwest’s heartland, offering a down-to-earth presence with academic and civic strength. It’s especially beneficial for service providers, educators, and organizations rooted in community impact.